TaRGET-II Data Portal

TaRGET-II Data Portal

Discover insights, Visualize trends from mouse exposomes

The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) Program was establised to address the role of the environment in disease susceptibility as a function of changes to the epigenome. The goals are to enhance our understanding of the relationship between exposure-induced perturbations of epigenetic marks in target versus surrogate tissues; determine conditions where these studies will be valid; and aid in the interpretation of the results of such studies.

Experiments by Assay

Experiments by Tissue

Experiments by Exposure

*TCDD = tetrachlorodibenzo-p-dioxin; BPA = bisphenol A; TBT = tributyltin; DEHP = di(2-ethylhexyl) phthalate; PM2.5 = particulate matter < 2.5μm (air pollution); Pb = Lead; Arsenite = Arsenic (As)

Tissue Dataset Matrix

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Assay	Experiments	Blood	Brain	Heart	Liver	Lung	Skin
ATAC	638	201	22		415
RNA	998	401	34	24	492	47
RRBS	71	36			35
WGBS	449	163	64		200		22
ChIP	627				627
Microarray	308	128	180

Age Dataset Matrix

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Assay	Experiments	3 weeks	5 weeks	20 weeks	40 weeks
ATAC	638	233		405
RNA	998	453		450	95
RRBS	71			71
WGBS	449			449
ChIP	627	33	35	526	33
Microarray	308			58	250

Summary of illumina microarray datasets (N = 308)

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Tissue	Age	Sex	Control	DEHP	Lead	BPA10ug	PM2.5	TBT	TCDD	BPA10mg
Blood	40 Weeks	Female	26	12	14				12
Blood	40 Weeks	Male	26	12	14				12
Cortex
	40 Weeks	Female	26			4		10	12
	40 Weeks	Male	24			4		24	12	6
	20 Weeks	Female	10			10				8
	20 Weeks	Male	10			10				10

Summary of ChIP datasets for Active Markers (N=480)

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				Aylor		Bartolomei			Biswal		Dolinoy			Mutlu		Walker
Age	Tissue	Marks	Sex	Control	TCDD	Control	BPA10mg	BPA10ug	Control	PM2.5	Control	DEHP	Pb	Control	PM2.5	Control	TBT
5 week
	Liver	H3K4me1	female
	Liver	H3K4me1	Male	5	5
	Liver	H3K4me3	female
	Liver	H3K4me3	Male	7	6
	Liver	H3K27ac	female
	Liver	H3K27ac	Male	6	6
20 week
	Liver	H3K4me1	female						4	5	6	5	6	6	6
	Liver	H3K4me1	Male	6	6	6	5	6	6	6	6	7	6	6	5	9	17
	Liver	H3K4me3	female						6	6	6	5	6	6	6
	Liver	H3K4me3	Male	6	6	6	6	6	6	6	5	7	6	6	5	9	19
	Liver	H3K27ac	female						5	6	6	5	6	6	6
	Liver	H3K27ac	Male	6	6	6	6	6	6	5	6	7	6	6	5	9	17
40 weeks
	Liver	H3K4me1	female
	Liver	H3K4me1	Male	6	4
	Liver	H3K4me3	female
	Liver	H3K4me3	Male	5	6
	Liver	H3K27ac	female
	Liver	H3K27ac	Male	6	6

Summary of ChIP datasets for Repressive Markers (N=147)

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				Aylor		Bartolomei			Biswal		Dolinoy			Mutlu		Walker
Age	Tissue	Marks	Sex	Control	TCDD	Control	BPA10mg	BPA10ug	Control	PM2.5	Control	DEHP	Pb	Control	PM2.5	Control	TBT
3 weeks
	Liver	H3K9me3	female													4	4
	Liver	H3K9me3	Male													3	6
	Liver	H3K27me3	female													4	4
	Liver	H3K27me3	Male													3	5
20 week
	Liver	H3K9me3	female
	Liver	H3K9me3	Male	6	6	5	3	4	6	6	6	5	6	6	5	2	12
	Liver	H3K27me3	female
	Liver	H3K27me3	Male	6	4	3	1	2	2		3	1	2	5	1	3	3